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Fast flip–flop of halogenated cobalt bis(dicarbollide) anion in a lipid bilayer membrane
Physical Chemistry Chemical Physics ( IF 2.9 ) Pub Date : 2017-09-07 00:00:00 , DOI: 10.1039/c7cp04207h Tatyana I. Rokitskaya 1, 2, 3, 4 , Irina D. Kosenko 4, 5, 6, 7 , Igor B. Sivaev 4, 5, 6, 7 , Yuri N. Antonenko 1, 2, 3, 4 , Vladimir I. Bregadze 4, 5, 6, 7
Physical Chemistry Chemical Physics ( IF 2.9 ) Pub Date : 2017-09-07 00:00:00 , DOI: 10.1039/c7cp04207h Tatyana I. Rokitskaya 1, 2, 3, 4 , Irina D. Kosenko 4, 5, 6, 7 , Igor B. Sivaev 4, 5, 6, 7 , Yuri N. Antonenko 1, 2, 3, 4 , Vladimir I. Bregadze 4, 5, 6, 7
Affiliation
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Transmembrane translocation (flip–flop) of cobalt bis(dicarbollide) (COSAN) anions, elicited by application of a voltage-jump across the lipid bilayer membrane, manifested itself in monoexponential electrical current transients in the microsecond time scale. Halogenation of COSAN led to multi-fold acceleration of the flip–flop, the effect increasing with the molecular weight of the halogens. The exception was a fluorinated analog which exhibited slowing of the translocation kinetics. Measurements of the fluorescence ratio of the dye di-4-ANEPPS in lipid vesicles showed significant differences in the adsorption of studied hydrophobic anions. Based on these data, it can be concluded that COSAN and COSAN-F2 were located on the surface of the lipid membrane in the cisoid conformation increasing the dipole potential of the lipid membrane, while other halogenated COSAN analogs were adsorbed in the transoid conformation. Differences in the flip–flop kinetics of COSAN analogs were attributed to variation in the molecular volume of the anions and their orientation on the membrane surface.
中文翻译：
脂质双层膜中的卤化钴双（双糖脂）阴离子快速翻转
跨脂质双层膜上施加电压跃变引起的钴双（双糖脂）（COSAN）阴离子的跨膜移位（触发器），表现为微秒级的单指数电流瞬变。COSAN的卤化导致触发器的多重加速，其效果随着卤素分子量的增加而增加。例外是氟化类似物，其表现出易位动力学减慢。脂质囊泡中染料di-4-ANEPPS的荧光比测量表明，所研究的疏水性阴离子的吸附存在显着差异。根据这些数据，可以得出结论，COSAN和COSAN-F 2它们以顺式构型位于脂质膜的表面，增加了脂质膜的偶极电位，而其他卤化的COSAN类似物被吸附在反式构型中。COSAN类似物的触发器动力学差异归因于阴离子分子体积的变化及其在膜表面的取向。
更新日期：2017-09-20
中文翻译：
脂质双层膜中的卤化钴双（双糖脂）阴离子快速翻转
跨脂质双层膜上施加电压跃变引起的钴双（双糖脂）（COSAN）阴离子的跨膜移位（触发器），表现为微秒级的单指数电流瞬变。COSAN的卤化导致触发器的多重加速，其效果随着卤素分子量的增加而增加。例外是氟化类似物，其表现出易位动力学减慢。脂质囊泡中染料di-4-ANEPPS的荧光比测量表明，所研究的疏水性阴离子的吸附存在显着差异。根据这些数据，可以得出结论，COSAN和COSAN-F 2它们以顺式构型位于脂质膜的表面，增加了脂质膜的偶极电位，而其他卤化的COSAN类似物被吸附在反式构型中。COSAN类似物的触发器动力学差异归因于阴离子分子体积的变化及其在膜表面的取向。
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