The formation of stable blood clots or hemostasis is essential to prevent major blood loss and death from excessive bleeding. However, the body’s own coagulation process is not able to accomplish hemostasis timely without the assistance of hemostatic agents. For developing the novel topical hemostatic agents, tissue adhesives and sealants, it is necessary to understand the coagulation process and hemostasis mechanism of different materials. Among hemostatic materials, polysaccharide is naturally derived polymer having excellent biodegradable and biocompatible properties. This review provides an overview of polysaccharide-based hemostatic materials and agents, including their advantages and drawbacks in the hemostatic application. Furthermore, the polysaccharide-based hemostatic materials with functions of anti-microbial and healing are also introduced.

中文翻译：

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多糖止血材料的设计开发及其止血机理

稳定的血凝块或止血的形成对于防止大量失血和因过度出血造成的死亡至关重要。但是，如果没有止血剂的帮助，人体自身的凝血过程就无法及时完成止血。为了开发新型的局部止血剂，组织粘合剂和密封剂，有必要了解不同材料的凝血过程和止血机理。在止血材料中，多糖是具有优异的可生物降解和生物相容性的天然衍生的聚合物。这篇综述概述了基于多糖的止血材料和药剂，包括它们在止血应用中的优缺点。此外，