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A mild halogenation of pyrazoles using sodium halide salts and Oxone
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2017-09-20 , DOI: 10.1016/j.tetlet.2017.09.042 Kathryn L. Olsen , Matthew R. Jensen , James A. MacKay
中文翻译:
使用卤化钠盐和Oxone对吡唑进行温和卤化
更新日期:2017-09-20
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2017-09-20 , DOI: 10.1016/j.tetlet.2017.09.042 Kathryn L. Olsen , Matthew R. Jensen , James A. MacKay
A mild, inexpensive, and operationally simple pyrazole halogenation method utilizing Oxone and sodium halide salts is reported. This work documents 17 examples of alkyl, aryl, allyl, and benzyl substituted 4-chloro and 4-bromopyrazoles, obtained in up to 93% yield. Reactions are performed in water under ambient conditions and generation of organic byproducts is avoided.
中文翻译:
使用卤化钠盐和Oxone对吡唑进行温和卤化
报道了一种温和,廉价且操作简单的吡唑卤化方法,该方法利用了Oxone和卤化钠盐。这项工作记录了烷基,芳基,烯丙基和苄基取代的4-氯和4-溴吡唑的17个实例,收率高达93%。反应在环境条件下在水中进行,避免了有机副产物的产生。