2-(2′-Hydroxyphenyl)-4(3H)-quinazolinone (HPQ) has been reported as a precipitating fluorescent molecule with excellent optical properties, such as large Stokes shift and strong fluorescence intensity. HPQF, a novel HPQ-based turn-on probe for localizable detection of fluoride ions, was designed, synthesized and fully characterized by ¹H NMR, ¹³C NMR and HRMS. As a chemogenic fluoride probe, the tert-butyldiphenylsilane moiety of HPQF can be easily cleaved by fluoride. After spontaneous 1,6-elimination, HPQ molecule was generated to emit fluorescence under the excitation light. Further study shows that HPQF exhibited high selectivity and sensitivity for detection of fluoride. In addition, HPQF was utilized for the detection of fluoride in living cells.

据报道，2-（2'-羟基苯基）-4（3 H）-喹唑啉酮（HPQ）是一种沉淀荧光分子，具有出色的光学特性，例如大的斯托克斯位移和强的荧光强度。设计，合成并通过¹ H NMR，¹³ C NMR和HRMS全面表征了HPQF，它是一种新颖的基于HPQ的可局部检测氟离子的开启探针。作为一种化学氟化物探针，叔HPQF的丁基二苯基硅烷部分很容易被氟化物裂解。自发的1,6-消除后，生成HPQ分子以在激发光下发出荧光。进一步的研究表明，HPQF对氟化物的检测具有很高的选择性和灵敏度。此外，HPQF还用于检测活细胞中的氟化物。