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Nanobiomedicine: Protein Coating of DNA Nanostructures for Enhanced Stability and Immunocompatibility (Adv. Healthcare Mater. 18/2017)
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-09-20 , DOI: 10.1002/adhm.201770093
Henni Auvinen 1 , Hongbo Zhang 2, 3 , Nonappa 4 , Alisa Kopilow 1 , Elina H. Niemelä 5 , Sami Nummelin 1 , Alexandra Correia 2 , Hélder A. Santos 2, 6 , Veikko Linko 1 , Mauri A. Kostiainen 1
Affiliation  

DNA origami nanostructures (purple double helix) can be coated with serum albumin proteins (green) to improve origami stability against DNA digesting enzymes, enhance delivery rates and, importantly, suppress the immune response. In article number 1700692, Henni Auvinen, Veikko Linko, Mauri Kostiainen, and co‐workers present a straightforward and modular coating strategy that can bring DNA origami–based drug delivery vehicles and nanodevices closer to clinical applications.
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中文翻译:

纳米生物医学:DNA纳米结构的蛋白质涂层可增强稳定性和免疫相容性(Adv。Healthcare Mater。18/2017)

DNA折纸纳米结构(紫色双螺旋)可以涂有血清白蛋白(绿色),以提高针对DNA消化酶的折纸稳定性,提高递送速度并重要地抑制免疫反应。在编号1700692中,Henni Auvinen,Veikko Linko,Mauri Kostiainen和同事们提出了一种简单而模块化的涂层策略,可以使基于DNA折纸的药物递送载体和纳米设备更接近于临床应用。
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更新日期:2017-09-20
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