Immune cell differentiation and function are crucially dependent on specific metabolic programs dictated by mitochondria, including the generation of ATP from the oxidation of nutrients and supplying precursors for the synthesis of macromolecules and post-translational modifications. The many processes that occur in mitochondria are intimately linked to their morphology that is shaped by opposing fusion and fission events. Exciting evidence is now emerging that demonstrates reciprocal crosstalk between mitochondrial dynamics and metabolism. Metabolic cues can control the mitochondrial fission and fusion machinery to acquire specific morphologies that shape their activity. We review the dynamic properties of mitochondria and discuss how these organelles interlace with immune cell metabolism and function.

中文翻译：

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免疫细胞新陈代谢和功能相互作用的线粒体动力学

免疫细胞的分化和功能至关重要地取决于线粒体决定的特定代谢程序，包括从营养物的氧化中生成ATP以及为大分子的合成和翻译后修饰提供前体。线粒体中发生的许多过程都与它们的形态密切相关，而形态是由相反的融合和裂变事件形成的。令人兴奋的证据正在出现，证明线粒体动力学与代谢之间存在相互影响。代谢线索可以控制线粒体的裂变和融合机制，以获取可改变其活性的特定形态。我们审查了线粒体的动力学特性，并讨论了这些细胞器如何与免疫细胞的新陈代谢和功能交织在一起。