The central pathogenetic role of type I interferons (IFNs) in several systemic autoimmune diseases is well established. Recent studies have also discovered a similar crucial role of type I IFNs in different components of metabolic disorders. Self nucleic acid-driven Toll-like receptor (TLR) activation in plasmacytoid dendritic cells (pDCs) and type I IFN induction appear to be the key initiating events shared by most of these autoimmune and metabolic diseases. Further strengthening this link, many patients with systemic autoimmunities also present with metabolic disorders. This concurrence of autoimmunities and metabolic disorders may be explained by a single pathogenetic continuum, and suggests shared targets for potential new therapies.

中文翻译：

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I型干扰素是否在致病性连续体中链接系统性自身免疫和代谢综合症？

I型干扰素（IFN）在几种系统性自身免疫性疾病中的中心致病作用已得到充分确立。最近的研究还发现，I型干扰素在代谢性疾病的不同成分中起着相似的关键作用。浆细胞样树突状细胞（pDC）中的自我核酸驱动的Toll样受体（TLR）激活和I型IFN诱导似乎是大多数这些自身免疫性和代谢性疾病共有的关键启动事件。进一步加强了这种联系，许多具有全身自身免疫性的患者也出现了代谢紊乱。自身免疫性和代谢紊乱的并发可以通过单个致病性连续体来解释，并暗示了潜在的新疗法的共同靶标。