We celebrated in 2016 the centenary of the death of Ilya Ilitch Metchnikov (1845–1916), the founding father of innate immunology. His studies on the description of macrophages, their phagocytic function, and their key role in eliminating microbes were recognized by the Nobel Prize in Physiology and Medicine, and constitute a cornerstone of immunology (https://www.nobelprize.org/nobel_prizes/medicine/laureates/1908/mechnikov-facts.html). Since then, macrophages are typically considered as tissue scavengers, that capture and destroy microbial intruders, thereby ensuring tissue protection and host defense against infections.

中文翻译：

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死因：感​​染后组织常性巨噬细胞坏死的调节

我们在2016年庆祝了先天免疫学的奠基人Ilya Ilitch Metchnikov（1845-1916）逝世一百周年。他对巨噬细胞的描述，其吞噬功能及其在消除微生物中的关键作用的研究获得了诺贝尔生理学和医学奖，并构成了免疫学的基石（https://www.nobelprize.org/nobel_prizes/medicine /laureates/1908/mechnikov-facts.html）。从那时起，巨噬细胞通常被视为组织清除剂，它们捕获并破坏微生物入侵者，从而确保组织保护和宿主防御感染。