Viewpoints on the immune system have evolved across different paradigms, including the clonal selection theory, the idiotypic network, and the danger and tolerance models. Herein, we propose that in multicellular organisms, where panoplies of cells from different germ layers interact and immune cells are constantly generated, the behavior of the immune system is defined by the rules governing cell survival, systems physiology and organismic homeostasis. Initially, these rules were imprinted at the single cell-protist level, but supervened modifications in the transition to multicellular organisms. This context determined the emergence of the ‘sensory immune system’, which operates in a s(c)ensor mode to ensure systems physiology, organismic homeostasis, and perpetuation of its replicating molecules.

中文翻译：

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S（c）免疫系统理论

关于免疫系统的观点已经在不同的范式中发展，包括克隆选择理论，独特型网络以及危险性和耐受性模型。本文中，我们提出在多细胞生物中，来自不同细菌层的细胞团相互作用并且不断产生免疫细胞，免疫系统的行为由控制细胞存活，系统生理和生物体内平衡的规则定义。最初，这些规则印在单细胞生物水平上，但是取代了向多细胞生物过渡的修饰。这种情况决定了“感觉免疫系统”的出现，该系统以（c）传感器模式运行，以确保系统生理，机体动态平衡以及其复制分子的持久存在。