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Common Senses
Trends in Immunology ( IF 13.1 ) Pub Date : 2017-09-13 00:00:00 , DOI: 10.1016/j.it.2017.09.001
Jacques Deguine 1
Affiliation  

Taste. Sight. Touch. Smell. Hearing. That M. Night Shyamalan movie. While the list has now grown far beyond those, we still associate senses with nervous systems, and by extension animals. Yet, any immune response, in any organism, must begin with the recognition of a threat, and properly calibrated immune ‘senses’ are critical to the avoidance of autoimmunity. This sense of self and non-self was originally thought to be encoded in the selection of adaptive cells. However, Charles Janeway in 1989 and Polly Matzinger in 1994 moved the field forward by introducing the notion of the innate sensing of molecular patterns characteristic of pathogens and cellular damage, respectively, as critical immune gatekeepers.

中文翻译:


 常识


品尝。视线。触碰。闻。听力。 M·奈特·沙马兰的那部电影。尽管这个清单现在已经远远超出了这些范围,但我们仍然将感官与神经系统联系起来,进而将动物联系起来。然而,任何生物体中的任何免疫反应都必须从识别威胁开始,而正确校准的免疫“感觉”对于避免自身免疫至关重要。这种自我和非自我的感觉最初被认为是在适应性细胞的选择中编码的。然而,1989 年的 Charles Janeway 和 1994 年的 Polly Matzinger 分别引入了病原体和细胞损伤特征分子模式的先天感知概念,将其作为关键的免疫守门人,从而推动了该领域的发展。

更新日期:2017-09-20
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