Efficient (cross-)presentation of antigens internalized by dendritic cells (DCs) requires vesicular communication between the early secretory and the endocytic/phagocytic pathways, in which the Sec22b protein has been suggested to have a key role. Here, we undertake a critical assessment of two new studies that evaluate the role of Sec22b using gene-targeted mice and come to contradictory conclusions.

中文翻译：

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MHC I类交叉演示：Sec22b上的舞台灯

被树突状细胞（DCs）内在化的抗原的有效（交叉）表达需要早期分泌和内吞/吞噬途径之间的囊泡连通，其中Sec22b蛋白被认为具有关键作用。在这里，我们对两项新研究进行了重要评估，这些研究使用基因靶向小鼠评估了Sec22b的作用，并得出了相互矛盾的结论。