Our assumptions on the identity and functions of Langerhans cells (LCs) of the epidermis have undergone considerable changes. Once thought to be prototypic representatives of the dendritic cell (DC) lineage, they are now considered to be a specialized subset of tissue-resident macrophages. Despite this, LCs display a remarkable mixture of properties. Like many tissue macrophages, they self-maintain locally. However, unlike tissue macrophages and similar to DCs, they homeostatically migrate to lymph nodes and present antigen to antigen-specific T cells. Current evidence indicates that the immune responses initiated by LCs are complex and dependent on antigenic properties and localization of the stimulus. This complexity is reflected in the recently demonstrated roles of LCs in type 17, regulatory, and humoral immune responses.

中文翻译：

---

朗格汉斯细胞–树突状细胞衣服中的巨噬细胞

我们对表皮朗格汉斯细胞（LC）的身份和功能的假设已经发生了很大的变化。一旦被认为是树突状细胞（DC）谱系的原型代表，现在它们被认为是组织驻留巨噬细胞的专门子集。尽管如此，LC仍显示出卓越的性能混合。像许多组织巨噬细胞一样，它们在局部自我维持。但是，与组织巨噬细胞不同，类似于DC，它们可以稳态迁移到淋巴结并将抗原呈递给抗原特异性T细胞。当前证据表明，LCs引发的免疫反应是复杂的，并且取决于抗原特性和刺激的定位。这种复杂性反映在最近显示的LC在17型，调节性和体液免疫反应中的作用中。