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Laminar Organization of Encoding and Memory Reactivation in the Parietal Cortex.
Neuron ( IF 14.7 ) Pub Date : 2017-Sep-13 , DOI: 10.1016/j.neuron.2017.08.033 Aaron A Wilber 1 , Ivan Skelin 2 , Wei Wu 3 , Bruce L McNaughton 2
Neuron ( IF 14.7 ) Pub Date : 2017-Sep-13 , DOI: 10.1016/j.neuron.2017.08.033 Aaron A Wilber 1 , Ivan Skelin 2 , Wei Wu 3 , Bruce L McNaughton 2
Affiliation
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Egocentric neural coding has been observed in parietal cortex (PC), but its topographical and laminar organization is not well characterized. We used multi-site recording to look for evidence of local clustering and laminar consistency of linear and angular velocity encoding in multi-neuronal spiking activity (MUA) and in the high-frequency (300-900 Hz) component of the local field potential (HF-LFP), believed to reflect local spiking activity. Rats were trained to run many trials on a large circular platform, either to LED-cued goal locations or as a spatial sequence from memory. Tuning to specific self-motion states was observed and exhibited distinct cortical depth-invariant coding properties. These patterns of collective local and laminar activation during behavior were reactivated in compressed form during post-experience sleep and temporally coupled to cortical delta waves and hippocampal sharp-wave ripples. Thus, PC neuron motion encoding is consistent across cortical laminae, and this consistency is maintained during memory reactivation.
中文翻译：
顶叶皮层编码和记忆重新激活的层状组织。
在顶叶皮层（PC）中观察到了自我中心神经编码，但其地形和层状组织尚未得到很好的表征。我们使用多站点记录来寻找多神经元尖峰活动（MUA）和局部场电位的高频（300-900 Hz）分量中线性和角速度编码的局部聚类和层流一致性的证据（ HF-LFP），据信反映了局部尖峰活动。老鼠被训练在一个大型圆形平台上进行多次试验，要么到达 LED 提示的目标位置，要么作为记忆中的空间序列。观察到对特定自运动状态的调整，并表现出明显的皮质深度不变编码特性。这些行为过程中集体局部和层流激活的模式在体验后睡眠期间以压缩形式重新激活，并暂时与皮质δ波和海马尖波波纹耦合。因此，PC 神经元运动编码在整个皮质层中是一致的，并且这种一致性在记忆重新激活期间得以维持。
更新日期：2017-09-20
中文翻译：
顶叶皮层编码和记忆重新激活的层状组织。
在顶叶皮层（PC）中观察到了自我中心神经编码，但其地形和层状组织尚未得到很好的表征。我们使用多站点记录来寻找多神经元尖峰活动（MUA）和局部场电位的高频（300-900 Hz）分量中线性和角速度编码的局部聚类和层流一致性的证据（ HF-LFP），据信反映了局部尖峰活动。老鼠被训练在一个大型圆形平台上进行多次试验，要么到达 LED 提示的目标位置，要么作为记忆中的空间序列。观察到对特定自运动状态的调整，并表现出明显的皮质深度不变编码特性。这些行为过程中集体局部和层流激活的模式在体验后睡眠期间以压缩形式重新激活，并暂时与皮质δ波和海马尖波波纹耦合。因此，PC 神经元运动编码在整个皮质层中是一致的，并且这种一致性在记忆重新激活期间得以维持。
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