Two recent studies (Cambier et al., 2017, Madigan et al., 2017) reveal in vivo functions for specific phenolic glycolipids (PGLs) in the mycobacteria that cause tuberculosis or leprosy. M. tuberculosis (and M. marinum) PGL promotes bacterial spread to growth-permissive macrophages, while M. leprae PGL-1 induces macrophages to cause nerve demyelination characteristic of human leprosy.

中文翻译：

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钓鱼寻找人类分枝杆菌感染的答案

最近的两项研究（Cambier等人，2017，Madigan等人，2017）揭示了分枝杆菌中引起结核病或麻风病的特定酚类糖脂（PGL）的体内功能。结核分枝杆菌（和结核分枝杆菌）PGL促进细菌扩散至允许生长的巨噬细胞，而麻风分枝杆菌PGL-1诱导巨噬细胞引起人类麻风病的神经脱髓鞘特征。