Some microbial metabolites can be immunomodulatory, but there is limited understanding of how these contribute to inter-individual variation in response to infection. In a recent study in Science, Steed et al. (2017) show that the bacterial metabolite desaminotyrosine (DAT) increases type I interferon expression, resulting in an improved immune response to influenza infection.

中文翻译：

---

拿DAT，流感！

某些微生物代谢产物可能具有免疫调节作用，但对这些代谢产物如何引起个体间感染变异的理解尚有限。在《科学》杂志的最新研究中，Steed等人。（2017）表明细菌代谢产物脱氨基酪氨酸（DAT）增加了I型干扰素的表达，从而改善了对流感感染的免疫反应。