Microglial cell function is implicated in the etiology of Alzheimer’s disease by human genetics. In this issue of Immunity, Krasemann et al. (2017) describe a gene expression signature associated with an APOE- and TREM2-dependent response of microglia to brain tissue damage that accumulates in aging and disease, defining an axis that might be amenable to therapeutic targeting.

中文翻译：

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两个基因的故事：小胶质细胞Apoe和Trem2

小胶质细胞功能通过人类遗传学与阿尔茨海默氏病的病因有关。在《免疫》一期中，Krasemann等人。（2017）描述了与小胶质细胞对APOE和TREM2依赖性的反应相关的基因表达特征，小胶质细胞对衰老和疾病中积累的脑组织损伤有一定的影响，并定义了可能适合治疗靶向的轴。