Inhibiting Treg cell function in tumors is an attractive strategy to improve anti-cancer immunity. In a pair of papers in Immunity and Cell, Ghosh and colleagues show that the canonical NF-κB subunits p65 and c-Rel have non-redundant, critical roles in promoting Treg cell development and function (Oh et al., 2017). Targeting c-Rel blunts Treg cell immunosuppressive activity in the tumor microenvironment and enhances anti-tumor T cell responses (Grinberg-Bleyer et al., 2017).

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推动相关Treg走向身份危机

抑制肿瘤中的Treg细胞功能是提高抗癌免疫力的诱人策略。在《免疫与细胞》（Immunity and Cell）的两篇论文中，Ghosh及其同事证明了经典的NF-κB亚基p65和c-Rel在促进Treg细胞发育和功能中具有非冗余的关键作用（Oh等人，2017）。在肿瘤微环境中靶向c-Rel钝化Treg细胞免疫抑制活性并增强抗肿瘤T细胞反应（Grinberg-Bleyer等人，2017）。