We appreciate the interest in our Personal View and thank Katrine Hygum and colleagues for their comments. We also recognise the complexity and multifactorial nature of diabetic bone disease, but still find strong indications for the key role of microvascular disease in diabetic bone disease. Although the results of the Danish register-based study¹ with data from more than 14 000 patients with diabetes suggested that neither diabetic eye disease nor neuropathy added to the risk of fractures, presence of diabetic kidney disease doubled the risk of fracture in comparison with patients with diabetes who had no microvascular disease.

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解开糖尿病和骨病之间的联系-作者的回复

非常感谢您对我们的个人观点感兴趣，并感谢Katrine Hygum及其同事的意见。我们也认识到糖尿病性骨病的复杂性和多因素性质，但仍发现微血管疾病在糖尿病性骨病中的关键作用有很强的适应症。尽管丹麦基于登记册的研究¹的结果来自超过14000例糖尿病患者的数据表明，糖尿病眼病和神经病变均未增加骨折风险，但与患者相比，糖尿病肾脏疾病的存在使骨折风险增加了一倍没有微血管疾病的糖尿病患者。