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Expanding Toolbox of Imageable Protein-Gold Hybrid Materials
Chemistry of Materials ( IF 7.2 ) Pub Date : 2017-09-19 00:00:00 , DOI: 10.1021/acs.chemmater.7b03011 Han Ding 1, 2 , Hongwei Li 1 , Xiaoliang Wang 1 , Yufeng Zhou 1 , Zhenhua Li 1 , J. Kalervo Hiltunen 1, 3 , Jiacong Shen 1 , Zhijun Chen 1
Chemistry of Materials ( IF 7.2 ) Pub Date : 2017-09-19 00:00:00 , DOI: 10.1021/acs.chemmater.7b03011 Han Ding 1, 2 , Hongwei Li 1 , Xiaoliang Wang 1 , Yufeng Zhou 1 , Zhenhua Li 1 , J. Kalervo Hiltunen 1, 3 , Jiacong Shen 1 , Zhijun Chen 1
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As a new class of bio-abiotic hybrid materials, a series of highly fluorescent self-assembled protein-gold hybrid materials (PGHMs) with different emission wavelengths (blue (B), green (G), yellow (Y), and red (R) colored under UV irradiation) are synthesized by using various combinations of proteins and free amino acids as stabilizer and reducing agents. The synthesis process was controllable by modulating the pH of the reaction solutions. The synthesized PGHMs (PGHM-Blue (PGHM-B), PGHM-Green (PGHM-G), PGHM-Yellow (PGHM-Y), and PGHM-Red (PGHM-R)) exhibited distinct fluorescent properties and showed low cytotoxicity as justified by a bacteria-based test system. The sizes of PGHMs are approximately 100 nm with gold core diameters 0.8–1.8 nm as shown by SEM and TEM images. The assembly of PGHMs was dynamic and occurred through a free radical associated cross-linking process. This general strategy expanded the toolbox of protein-gold hybrid materials. The photostable bio-abiotic hybrid fluorescent nanomaterials can be an alternative to conventional fluorescent probes such as organic dyes and quantum dots for bioimaging studies.
中文翻译：
可成像的蛋白质-金杂化材料的扩展工具箱
作为一类新型的生物非生物杂化材料，一系列具有不同发射波长（蓝色（B），绿色（G），黄色（Y）和红色（ R）在紫外线照射下着色）是通过使用蛋白质和游离氨基酸的各种组合作为稳定剂和还原剂来合成的。通过调节反应溶液的pH可以控制合成过程。合成的PGHMs（PGHM-Blue（PGHM-B），PGHM-Green（PGHM-G），PGHM-Yellow（PGHM-Y）和PGHM-Red（PGHM-R））表现出独特的荧光特性并显示出较低的细胞毒性基于细菌的测试系统是合理的。PGHM的尺寸约为100 nm，金芯直径为0.8–1.8 nm，如SEM和TEM图像所示。PGHMs的组装是动态的，并且是通过自由基相关的交联过程发生的。这种通用策略扩展了蛋白质-金杂化材料的工具箱。光稳定的生物-非生物杂合荧光纳米材料可以替代常规荧光探针，例如用于生物成像研究的有机染料和量子点。
更新日期：2017-09-20
中文翻译：
可成像的蛋白质-金杂化材料的扩展工具箱
作为一类新型的生物非生物杂化材料，一系列具有不同发射波长（蓝色（B），绿色（G），黄色（Y）和红色（ R）在紫外线照射下着色）是通过使用蛋白质和游离氨基酸的各种组合作为稳定剂和还原剂来合成的。通过调节反应溶液的pH可以控制合成过程。合成的PGHMs（PGHM-Blue（PGHM-B），PGHM-Green（PGHM-G），PGHM-Yellow（PGHM-Y）和PGHM-Red（PGHM-R））表现出独特的荧光特性并显示出较低的细胞毒性基于细菌的测试系统是合理的。PGHM的尺寸约为100 nm，金芯直径为0.8–1.8 nm，如SEM和TEM图像所示。PGHMs的组装是动态的，并且是通过自由基相关的交联过程发生的。这种通用策略扩展了蛋白质-金杂化材料的工具箱。光稳定的生物-非生物杂合荧光纳米材料可以替代常规荧光探针，例如用于生物成像研究的有机染料和量子点。
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