Selection of molecular targets based on disease understanding is a dominant paradigm in drug discovery. We argue that a focus on classes of targets with central roles in biology provides a complimentary approach that has higher quality outcomes in early discovery efforts.

中文翻译：

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目标类药物发现

基于疾病理解的分子靶标选择是药物发现中的主要范例。我们认为，对在生物学中起中心作用的目标类别的关注提供了一种互补的方法，该方法在早期发现工作中具有更高的质量。