The introduction of a cyclopropyl group is critical for imparting colibactin with the ability to cleave DNA. Nonribosomal peptide synthetase ClbH and polyketide synthase ClbI are now shown to work in concert to convert S-adenosylmethionine into this cyclopropyl group.

中文翻译：

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生物合成：SAM可回收大肠菌素

环丙基的引入对于赋予大肠菌素具有切割DNA的能力是至关重要的。现在显示非核糖体肽合成酶ClbH和聚酮化合物合酶ClbI协同工作，可将S-腺苷甲硫氨酸转化为该环丙基。