A general strategy to add diversity to ruthenium arene complexes with bioactive organic compounds via a coordinated (4-hydroxyphenyl)diphenylphosphine ligand,Dalton Transactions

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A general strategy to add diversity to ruthenium arene complexes with bioactive organic compounds via a coordinated (4-hydroxyphenyl)diphenylphosphine ligand
Dalton Transactions ( IF 4 ) Pub Date : 2017-06-19 00:00:00 , DOI: 10.1039/c7dt02062g
Lorenzo Biancalana _{1,

2,

3,

4} , Lucinda K. Batchelor _{5,

6,

7,

8} , Alice De Palo _{1,

2,

3,

4} , Stefano Zacchini _{4,

9,

10,

11} , Guido Pampaloni _{1,

2,

3,

4} , Paul J. Dyson _{5,

6,

7,

8} , Fabio Marchetti _{1,

2,

3,

4}

Affiliation

Esterification of (4-hydroxyphenyl)diphenylphosphine, coordinated to the [Ru(η⁶-p-cymene)Cl₂] fragment, allows a series of bioactive carboxylic acids to be introduced directly into the organometallic molecule. Evaluation of the compounds on human ovarian cancer cells reveals synergistic enhancements in their antiproliferative activity relative to their bioactive organic and organometallic precursors.

中文翻译：

通过配位的（4-羟苯基）二苯基膦配体为钌芳烃配合物与生物活性有机化合物增加多样性的一般策略

（4-羟基苯基）二苯基膦，配位到的酯化的[Ru（η ⁶ - p -cymene）氯₂ ]片段，允许一系列生物活性羧酸的直接引入有机金属分子。化合物对人卵巢癌细胞的评估显示，相对于其生物活性有机和有机金属前体，其抗增殖活性具有协同增强作用。

更新日期：2017-09-20

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