Self-quenched ferrocenyl diketopyrrolopyrrole organic nanoparticles with amplifying photothermal effect for cancer therapy,Chemical Science

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Self-quenched ferrocenyl diketopyrrolopyrrole organic nanoparticles with amplifying photothermal effect for cancer therapy
Chemical Science ( IF 7.6 ) Pub Date : 2017-09-05 00:00:00 , DOI: 10.1039/c7sc03351f
Pingping Liang _{1,

2,

3,

4,

5} , Qianyun Tang _{1,

2,

3,

4,

5} , Yu Cai _{1,

2,

3,

4,

5} , Gongyuan Liu _{1,

2,

3,

4,

5} , Weili Si _{1,

2,

3,

4,

5} , Jinjun Shao _{1,

2,

3,

4,

5} , Wei Huang _{1,

2,

3,

4,

5} , Qi Zhang _{4,

6,

7,

8} , Xiaochen Dong _{1,

2,

3,

4,

5}

Affiliation

Organic nanoparticles (NPs) with near-infrared absorbance possess high photothermal conversion (PTC) efficiency and an excellent photoacoustic signal, presenting a great prospect for photoacoustic imaging (PAI)-guided photothermal therapy (PTT). Herein, a novel diketopyrrolopyrrole derivative (DPPCN-Fc) is synthesized for use as a PTT agent with PAI performance. Due to photo-induced electron transfer (PET), the two flanked ferrocene moieties significantly quench the radiative decay and intersystem crossing process, resulting in an enhanced nonradiative transition, and an amplifying photothermal effect is observed. Exposing the DPPCN-Fc NP aqueous dispersion (100 μg mL⁻¹) to 730 nm (1.0 W cm⁻²) laser radiation results in a temperature elevation of 33.4 °C within 10 min and the PTC efficiency reaches up to 59.1%, which is higher than most reported photothermal therapeutic agents. Furthermore, under irradiation from 730 nm lasers, cancer cells could be completely killed in vivo due to the amplifying photothermal effects. Therefore, the as-prepared DPPCN-Fc NPs are a promising cancer theranostic agent for photoacoustic imaging-guided cancer photothermal therapy.

中文翻译：

自淬灭的二茂铁基二酮吡咯并吡咯有机纳米颗粒具有增强的光热效应，可用于癌症治疗

具有近红外吸收率的有机纳米颗粒（NPs）具有很高的光热转换（PTC）效率和出色的光声信号，为光声成像（PAI）引导的光热疗法（PTT）展示了广阔的前景。在此，合成了新颖的二酮吡咯并吡咯衍生物（DPPCN-Fc），用作具有PAI性能的PTT剂。由于光致电子转移（PET），两个侧链的二茂铁部分显着抑制了辐射衰变和系统间交叉过程，从而增强了非辐射跃迁，并观察到放大的光热效应。将DPPCN-Fc NP水分散液（100μgmL ^-1）暴露于730 nm（1.0 W cm ^-2））激光辐射导致10分钟内温度升高33.4°C，PTC效率高达59.1％，高于大多数报道的光热治疗剂。此外，在730 nm激光的照射下，由于放大的光热效应，癌细胞可以在体内被完全杀死。因此，所制备的DPPCN-Fc NP是用于光声成像引导的癌症光热疗法的有希望的癌症治疗药物。

更新日期：2017-09-20

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