Metal–organic framework enhanced electromembrane extraction – a conceptual study using basic drugs as model substances,Analytical Methods

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Metal–organic framework enhanced electromembrane extraction – a conceptual study using basic drugs as model substances
Analytical Methods ( IF 2.7 ) Pub Date : 2017-08-24 00:00:00 , DOI: 10.1039/c7ay01093a
Ali Reza Fakhari _{1,

2,

3,

4} , Sajad Asadi _{1,

2,

3,

4} , Hasan Mohammadi Kosalar _{1,

2,

3,

4} , Ali Sahragard _{1,

2,

3,

4} , Alireza Hashemzadeh _{1,

2,

3,

4} , Mostafa M. Amini _{1,

2,

3,

4}

Affiliation

This work aims to use an appealing metal–organic framework (MOF), MIL-101(Cr), for the enhancement of electromembrane extraction efficiency. The use of MIL-101(Cr) in the supported liquid membrane (SLM) enhanced the analyte partition coefficient within the membrane, resulting in the enhancement of analyte transport. The optimization of the different variables affecting the proposed method was carried out in order to achieve the best extraction efficiency. Three narcotic drugs, including methadone, methamphetamine, and tramadol, were selected as model basic drugs. Optimal extractions were obtained with 2-nitrophenyl octyl ether, containing 2.0 mg mL⁻¹ MIL-101(Cr) as the SLM and 125 V as the driving force with pHs of 4.0 and 1.0 for donor and acceptor solutions, respectively. Equilibrium extraction conditions were obtained after 25 min of operation with a stirring rate of 1250 rpm. Under the optimized extraction conditions, the proposed technique provided good linearity (>0.997), repeatability (RSD = 6.7–9.6%, n = 5), low limits of detection (0.30–0.91 ng mL⁻¹), excellent preconcentration (132–190) and high recoveries (66–95%). Finally, the developed method coupled with CE-UV was successfully employed for the determination of the three narcotic basic drugs in biological samples, including plasma and urine.

中文翻译：

金属有机框架增强了电膜的提取–使用基本药物作为模型物质的概念研究

这项工作旨在使用有吸引力的金属有机框架（MOF）MIL-101（Cr），以提高电膜的提取效率。在支撑液膜（SLM）中使用MIL-101（Cr）可以提高膜内分析物的分配系数，从而增强分析物的运输。为了实现最佳提取效率，对影响所提出方法的不同变量进行了优化。选择了三种麻醉药品，包括美沙酮，甲基苯丙胺和曲马多作为基础药物。用含有2.0 mg mL ^-1的2-硝基苯基辛基醚获得最佳提取物MIL-101（Cr）作为SLM，125 V作为驱动力，供体溶液和受体溶液的pH分别为4.0和1.0。在操作25分钟后，以1250 rpm的搅拌速度获得平衡萃取条件。在优化的提取条件下，所提出的技术具有良好的线性（> 0.997），可重复性（RSD = 6.7–9.6％，n = 5），低检测限（0.30–0.91 ng mL ^-1），出色的预浓缩（132– 190）和高回收率（66-95％）。最后，已开发的方法与CE-UV结合成功地用于测定生物样品（包括血浆和尿液）中的三种麻醉性基本药物。

更新日期：2017-09-19

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