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Plasma treatment as an efficient tool for controlled drug release from polymeric materials: A review
Journal of Controlled Release ( IF 10.5 ) Pub Date : 2017-09-19 , DOI: 10.1016/j.jconrel.2017.09.023
D.G. Petlin , S.I. Tverdokhlebov , Y.G. Anissimov

One of the most actively developing fields in modern medicine is controlled drug delivery, an ability to keep optimal concentration of a drug at the desired body location. In particular, the most attention for potential use as drug delivery vehicles is drawn towards biodegradable polymeric materials. This is due to the versatility of tools for their fabrication, as well as due to the need to extract them after implantation being eliminated. In order to enhance polymer characteristics in terms of biocompatibility their surface can be functionalized. Plasma treatment is a method for the modification of material surface properties, which spans a wide range of applications in tissue engineering and regenerative medicine. The main advantage of this method is its ability to modify a polymeric surface without altering the bulk properties of materials, thus preserving original mechanical characteristics. Moreover, plasma modification is well-known for its speed, excluded need for solvents, and scalability. Recently, this approach has been gaining popularity for drug delivery applications. The applications of plasma treatment during the fabrication of drug delivery vehicles include surface activation, enhanced wettability, the fabrication of hydrophobic barrier layer, induced cross-linking and improved drug loading. This review covers the variety of approaches, applied to different polymeric biomaterials, including non-woven meshes, films, microparticles, microneedles and tablets, in order to achieve a controlled drug release. The applications of drug delivery devices with an implemented plasma treatment modification are also described.



中文翻译:

等离子体处理作为控制聚合物材料中药物释放的有效工具

在现代医学中最活跃的发展领域之一是受控的药物输送,这是一种将药物保持在所需身体位置的最佳浓度的能力。特别地,作为药物递送载体的潜在用途的最受关注是可生物降解的聚合物材料。这是由于工具制造的多功能性,以及消除了在植入后需要将其拔出的原因。为了增强生物相容性方面的聚合物特性,可以对其表面进行功能化。等离子体处理是一种改变材料表面性能的方法,在组织工程和再生医学中有着广泛的应用。这种方法的主要优点是能够在不改变材料整体性能的情况下修饰聚合物表面,因此保留了原始的机械特性。此外,等离子体改性因其速度快,排除了溶剂需求和可扩展性而闻名。最近,这种方法已在药物递送应用中获得普及。在药物输送载体的制造过程中等离子处理的应用包括表面活化,增强的润湿性,疏水性阻挡层的制造,诱导的交联和改善的药物载量。这篇综述涵盖了各种方法,这些方法适用于不同的聚合物生物材料,包括无纺网,薄膜,微粒,微针和片剂,以实现受控的药物释放。还描述了具有实现的等离子体处理修改的药物输送装置的应用。等离子体改性因其速度快,无需溶剂和可扩展性而闻名。最近,这种方法已在药物递送应用中获得普及。在药物输送载体的制造过程中等离子处理的应用包括表面活化,增强的润湿性,疏水性阻挡层的制造,诱导的交联和改善的药物载量。这篇综述涵盖了各种方法,这些方法适用于不同的聚合物生物材料,包括无纺网,薄膜,微粒,微针和片剂,以实现受控的药物释放。还描述了具有实现的等离子体处理修改的药物输送装置的应用。等离子体改性因其速度快,无需溶剂和可扩展性而闻名。最近,这种方法已在药物递送应用中获得普及。在药物输送载体的制造过程中等离子处理的应用包括表面活化,增强的润湿性,疏水性阻挡层的制造,诱导的交联和改善的药物载量。这篇综述涵盖了各种方法,这些方法适用于不同的聚合物生物材料,包括无纺网,薄膜,微粒,微针和片剂,以实现受控的药物释放。还描述了具有实现的等离子体处理修改的药物输送装置的应用。这种方法已经在药物递送应用中获得普及。在药物输送载体的制造过程中等离子处理的应用包括表面活化,增强的润湿性,疏水性阻挡层的制造,诱导的交联和改善的药物载量。这篇综述涵盖了各种方法,这些方法适用于不同的聚合物生物材料,包括无纺网,薄膜,微粒,微针和片剂,以实现受控的药物释放。还描述了具有实现的等离子体处理修改的药物输送装置的应用。这种方法已经在药物递送应用中获得普及。在药物输送载体的制造过程中等离子处理的应用包括表面活化,增强的润湿性,疏水性阻挡层的制造,诱导的交联和改善的药物载量。这篇综述涵盖了各种方法,这些方法适用于不同的聚合物生物材料,包括无纺网,薄膜,微粒,微针和片剂,以实现受控的药物释放。还描述了具有实现的等离子体处理修改的药物输送装置的应用。疏水阻隔层的制造,诱导的交联和改善的药物载量。这篇综述涵盖了各种方法,这些方法适用于不同的聚合物生物材料,包括无纺网,薄膜,微粒,微针和片剂,以实现受控的药物释放。还描述了具有实现的等离子体处理修改的药物输送装置的应用。疏水阻隔层的制造,诱导的交联和改善的药物载量。这篇综述涵盖了各种方法,这些方法适用于不同的聚合物生物材料,包括无纺网,薄膜,微粒,微针和片剂,以实现受控的药物释放。还描述了具有实现的等离子体处理修改的药物输送装置的应用。

更新日期:2017-09-19
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