A magnetoresistive biosensor was demonstrated using an InSb-based semiconductor channel. The Fe₃O₄ nanoparticle was linked with a target antigen via a capture antibody in the reagent, and a detection antibody immobilized on an InSb channel was shown to selectively bind to the antigen-capture antibody-nanoparticle complex. The detected magnetic nanoparticles produced a stray magnetic field that induced a change in the resistance of the channel due to the Lorentz force. The antigen concentration was proportional to the number of nanoparticles attached to the sensor surface, and hence could be determined by measuring the magnetoresistance level of the sensing channel. This antigen-antibody reaction sensor was shown to detect an extremely small amount of liver cancer antigen, at a concentration as low as 1 pg/ml. The systematic tests we carried out also confirmed the good selectivity and reusability of this biosensor.

使用基于InSb的半导体通道演示了磁阻生物传感器。铁₃ O ₄纳米颗粒通过试剂中的捕获抗体与靶标抗原连接，固定在InSb通道上的检测抗体显示与抗原捕获抗体-纳米颗粒复合物选择性结合。检测到的磁性纳米颗粒产生杂散磁场，该杂散磁场会由于洛伦兹力而引起通道电阻的变化。抗原浓度与附着在传感器表面的纳米颗粒数量成正比，因此可以通过测量传感通道的磁阻水平来确定。该抗原-抗体反应传感器显示出可检测到极少量的肝癌抗原，其浓度低至1 pg / ml。我们进行的系统测试也证实了该生物传感器的良好选择性和可重复使用性。