Intramolecular Thioether Crosslinking to Increase the Proteolytic Stability of Affibody Molecules,ChemBioChem

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Intramolecular Thioether Crosslinking to Increase the Proteolytic Stability of Affibody Molecules
ChemBioChem ( IF 2.6 ) Pub Date : 2017-09-19 07:15:28 , DOI: 10.1002/cbic.201700350
Anders Nilsson ₁ , Joel Lindgren ₁ , Amelie Eriksson Karlström ₁

Affiliation

Orally available protein drugs: Thioether crosslinks were introduced into an epidermal growth factor receptor (EGFR)-binding affibody molecule to establish a general method for increasing stability against proteolytic degradation. All crosslinked protein variants showed increased proteolytic stability with retained thermal stability and high-affinity binding to EGFR, relative to an unmodified control.

中文翻译：

分子内硫醚交联增加Affibody分子的蛋白水解稳定性。

口服蛋白质药物：将硫醚交联引入表皮生长因子受体（EGFR）结合亲和分子中，以建立提高抗蛋白水解降解稳定性的通用方法。相对于未修饰的对照，所有交联的蛋白质变体均显示出增加的蛋白水解稳定性，并保留了热稳定性和与EGFR的高亲和力结合。

更新日期：2017-09-19

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