Chronic wounds do not heal in an orderly fashion in part due to the lack of timely release of biological factors essential for healing. Topical administration of various therapeutic factors at different stages is shown to enhance the healing rate of chronic wounds. Developing a wound dressing that can deliver biomolecules with a predetermined spatial and temporal pattern would be beneficial for effective treatment of chronic wounds. Here, an actively controlled wound dressing is fabricated using composite fibers with a core electrical heater covered by a layer of hydrogel containing thermoresponsive drug carriers. The fibers are loaded with different drugs and biological factors and are then assembled using textile processes to create a flexible and wearable wound dressing. These fibers can be individually addressed to enable on‐demand release of different drugs with a controlled temporal profile. Here, the effectiveness of the engineered dressing for on‐demand release of antibiotics and vascular endothelial growth factor (VEGF) is demonstrated for eliminating bacterial infection and inducing angiogenesis in vitro. The effectiveness of the VEGF release on improving healing rate is also demonstrated in a murine model of diabetic wounds.

中文翻译：

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用于时间和剂量控制的药物输送的纺织品敷料

慢性伤口不能按部就班地愈合，部分原因是缺乏及时释放对治愈必不可少的生物学因素。在不同阶段局部施用各种治疗因子可提高慢性伤口的愈合速度。开发可以递送具有预定的空间和时间模式的生物分子的伤口敷料将有利于慢性伤口的有效治疗。在这里，使用复合纤维制造主动控制的伤口敷料，复合纤维具有芯电加热器，芯电加热器被包含热响应性药物载体的水凝胶层覆盖。纤维中负载了不同的药物和生物因子，然后使用纺织工艺进行组装，以创建灵活且可穿戴的伤口敷料。可以对这些纤维进行单独处理，以实现具有受控时间特性的不同药物的按需释放。在这里，证明了该工程敷料对抗生素和血管内皮生长因子（VEGF）的按需释放的有效性，可消除细菌感染并诱导体外血管生成。在糖尿病伤口的鼠模型中也证明了VEGF释放对提高治愈率的有效性。