Hsp90 is a conserved molecular chaperone that facilitates the folding and function of client proteins. Hsp90 function is dynamically regulated by interactions with co-chaperones and by post-translational modifications. In the fungal pathogen Candida albicans, Hsp90 enables drug resistance and virulence by stabilizing diverse signal transducers. Here, we review studies that have unveiled regulators of Hsp90 function, as well as downstream effectors that govern the key virulence traits of morphogenesis and drug resistance. We highlight recent work mapping the Hsp90 genetic network in C. albicans under diverse environmental conditions, and how these interactions provide insight into circuitry important for drug resistance, morphogenesis, and virulence. Ultimately, elucidating the Hsp90 chaperone network will aid in the development of therapeutics to treat fungal disease.

Hsp90是一种保守的分子伴侣，可促进客户蛋白质的折叠和功能。Hsp90功能是通过与伴侣伴侣的相互作用和翻译后修饰来动态调节的。在真菌病原体白色念珠菌中， Hsp90通过稳定各种信号转导子来实现耐药性和毒力。在这里，我们回顾了揭示Hsp90功能调节子的研究，以及控制形态发生和耐药性关键毒力特征的下游效应子。我们着重介绍在白色念珠菌中绘制Hsp90遗传网络的最新工作在不同的环境条件下，以及这些相互作用如何提供对耐药性，形态发生和毒力重要的电路的见解。最终，阐明Hsp90伴侣网络将有助于开发治疗真菌病的疗法。