Pd-catalyzed allylations of cyclic bis-allylic substrates, carried out either as two separate steps or in a pseudo-domino fashion, can generate 2-carboxyl-hexahydroindoles bearing an unsaturation in different positions. Sequential homologation, and epoxidation or syn-dihydroxylation steps were investigated to access analogues of the bicyclic 2-carboxyl-6-hydroxyoctahydroindole motif of aeruginosins, a family of peptides displaying serine protease inhibitor activity.

中文翻译：

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分散的Pd催化的烯丙基化过程中的2-羧基-6-羟基八氢吲哚（CHOI）单元的类似物：选择性与双键位置的关系

钯催化的环状双烯丙基底物的烯丙基化，以两个单独的步骤或以假多米诺方式进行，可以生成在不同位置带有不饱和键的2-羧基-六氢吲哚。为了获得铜绿素酶的双环2-羧基-6-羟基八氢吲哚基序的序列类似物，环氧化或顺-二羟基化步骤进行了研究，这是一个显示丝氨酸蛋白酶抑制剂活性的肽家族。