The high comorbidity among neuropsychiatric disorders suggests a possible common neurobiological phenotype. Resting-state regional cerebral blood flow (CBF) can be measured noninvasively with magnetic resonance imaging (MRI) and abnormalities in regional CBF are present in many neuropsychiatric disorders. Regional CBF may also provide a useful biological marker across different types of psychopathology. To investigate CBF changes common across psychiatric disorders, we capitalized upon a sample of 1042 youths (ages 11-23 years) who completed cross-sectional imaging as part of the Philadelphia Neurodevelopmental Cohort. CBF at rest was quantified on a voxelwise basis using arterial spin labeled perfusion MRI at 3T. A dimensional measure of psychopathology was constructed using a bifactor model of item-level data from a psychiatric screening interview, which delineated four factors (fear, anxious-misery, psychosis and behavioral symptoms) plus a general factor: overall psychopathology. Overall psychopathology was associated with elevated perfusion in several regions including the right dorsal anterior cingulate cortex (ACC) and left rostral ACC. Furthermore, several clusters were associated with specific dimensions of psychopathology. Psychosis symptoms were related to reduced perfusion in the left frontal operculum and insula, whereas fear symptoms were associated with less perfusion in the right occipital/fusiform gyrus and left subgenual ACC. Follow-up functional connectivity analyses using resting-state functional MRI collected in the same participants revealed that overall psychopathology was associated with decreased connectivity between the dorsal ACC and bilateral caudate. Together, the results of this study demonstrate common and dissociable CBF abnormalities across neuropsychiatric disorders in youth.

中文翻译：

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常见的和可分离的局部脑血流差异与跨类别诊断的精神病理学维度相关。

神经精神疾病之间的高合并症表明可能存在共同的神经生物学表型。静息态局部脑血流量 (CBF) 可以通过磁共振成像 (MRI) 无创测量，并且局部 CBF 异常存在于许多神经精神疾病中。区域 CBF 还可能为不同类型的精神病理学提供有用的生物标记。为了调查精神疾病中常见的 CBF 变化，我们利用了 1042 名青少年（11-23 岁）样本，他们作为费城神经发育队列的一部分完成了横断面成像。使用 3T 动脉自旋标记灌注 MRI 在体素基础上对静息 CBF 进行量化。使用来自精神病学筛查访谈的项目级数据的双因素模型构建了精神病理学的维度测量，该模型描绘了四个因素（恐惧、焦虑痛苦、精神病和行为症状）加上一个一般因素：整体精神病理学。总体精神病理学与多个区域的灌注升高相关，包括右背侧前扣带皮层 (ACC) 和左喙侧 ACC。此外，几个集群与精神病理学的特定维度相关。精神病症状与左额叶和岛叶灌注减少有关，而恐惧症状与右侧枕叶/梭状回和左侧膝下 ACC 灌注减少有关。使用在同一参与者中收集的静息态功能 MRI 进行的后续功能连接分析显示，总体精神病理学与背侧 ACC 和双侧尾状核之间的连接性降低有关。总之，这项研究的结果证明了青少年神经精神疾病中常见且可分离的 CBF 异常。