The Integrative Psychiatric Research (iPSYCH) consortium has established a large Danish population-based Case-Cohort sample (iPSYCH2012) aimed at unravelling the genetic and environmental architecture of severe mental disorders. The iPSYCH2012 sample is nested within the entire Danish population born between 1981 and 2005, including 1 472 762 persons. This paper introduces the iPSYCH2012 sample and outlines key future research directions. Cases were identified as persons with schizophrenia (N=3540), autism (N=16 146), attention-deficit/hyperactivity disorder (N=18 726) and affective disorder (N=26 380), of which 1928 had bipolar affective disorder. Controls were randomly sampled individuals (N=30 000). Within the sample of 86 189 individuals, a total of 57 377 individuals had at least one major mental disorder. DNA was extracted from the neonatal dried blood spot samples obtained from the Danish Neonatal Screening Biobank and genotyped using the Illumina PsychChip. Genotyping was successful for 90% of the sample. The assessments of exome sequencing, methylation profiling, metabolome profiling, vitamin-D, inflammatory and neurotrophic factors are in progress. For each individual, the iPSYCH2012 sample also includes longitudinal information on health, prescribed medicine, social and socioeconomic information, and analogous information among relatives. To the best of our knowledge, the iPSYCH2012 sample is the largest and most comprehensive data source for the combined study of genetic and environmental aetiologies of severe mental disorders.

中文翻译：

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iPSYCH2012病例队列样本：揭示严重精神障碍的遗传和环境结构的新方向。

整合精神病学研究（iPSYCH）联盟建立了一个大型的丹麦人群为基础的病例队列样本（iPSYCH2012），旨在揭示严重精神障碍的遗传和环境结构。iPSYCH2012样本嵌套在1981年至2005年之间出生的整个丹麦人口中，包括1 472 762人。本文介绍了iPSYCH2012示例，并概述了未来的主要研究方向。病例确定为精神分裂症（N = 3540），自闭症（N = 16146），注意力缺陷/多动障碍（N = 18726）和情感障碍（N = 26380），其中1928年患有双相情感障碍。对照是随机抽样的个体（N = 30 000）。在86 189个人的样本中，共有57 377个人患有至少一种严重的精神障碍。从丹麦新生儿筛查生物库获得的新生儿干血斑样品中提取DNA，并使用Illumina PsychChip进行基因分型。90％的样本均成功进行了基因分型。目前正在评估外显子组测序，甲基化谱，代谢组谱，维生素D，炎症和神经营养因子。对于每个人，iPSYCH2012样本还包括有关健康的纵向信息，处方药，社会和社会经济信息以及亲戚之间的类似信息。据我们所知，iPSYCH2012样本是对严重精神障碍的遗传和环境病因进行综合研究的最大，最全面的数据源。