The Fulani ethnic group has relatively better protection from Plasmodium falciparum malaria, as reflected by fewer symptomatic cases of malaria, lower infection rates, and lower parasite densities compared to sympatric ethnic groups<strong>.</strong> However, the basis for this lower susceptibility to malaria by the Fulani is unknown. We have performed a pilot study to examine global transcription and DNA methylation patterns in specific immune cell populations in the Fulani to elucidate the mechanisms that confer the lower susceptibility to P.falciparum malaria. When we compared uninfected and infected Fulani individuals, in contrast to uninfected and infected individuals from the sympatric ethnic group Mossi, we observed a key difference: a strong transcriptional response was only detected in the monocyte fraction of the Fulani, where over 1000 genes were significantly differentially expressed upon P.falciparum infection.

与同胞族相比，富拉尼族对恶性疟原虫的防护相对较好，这是因为有症状的疟疾病例较少，感染率较低且寄生虫密度较低。</ strong> Fulani对疟疾的易感性未知。我们进行了一项前期研究，以检查富拉尼中特定免疫细胞群体的总体转录和DNA甲基化模式，以阐明导致恶性疟原虫敏感性降低的机制。疟疾。当我们比较未感染和感染的Fulani个体时，与同族民族Mossi的未感染和感染的个体形成对比，我们观察到一个关键的区别：仅在Fulani的单核细胞部分中检测到了强转录应答，其中显着超过1000个基因在恶性疟原虫感染中差异表达。