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Neurodevelopmental disorders: A transcription-targeting target
Nature Reviews Neuroscience ( IF 28.7 ) Pub Date : 2017-09-19 00:00:00 , DOI: 10.1038/nrn.2017.123
Natasha Bray

Fragile X mental retardation protein (FMRP) represses the transcription of many target genes, including genes that encode chromatin-associated proteins. Loss of FMRP leads to fragile X syndrome (FXS); however, whether misregulation of chromatin-associated proteins contributes to FXS is unclear. Korb et al. showed that

中文翻译:

神经发育障碍:靶向转录的目标

脆弱的X智力低下蛋白(FMRP)抑制许多靶基因的转录,包括编码染色质相关蛋白的基因。FMRP的丢失会导致脆性X综合征(FXS);然而,尚不清楚染色质相关蛋白的失调是否会导致FXS。Korb等。表明
更新日期:2017-09-19
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