The emerging complexity of the transcriptional landscape poses great challenges to our conventional preconceptions of how the genome regulates brain function and dysfunction. Non-protein-coding RNAs (ncRNAs) confer a high level of intricate and dynamic regulation of various molecular processes in the CNS and they have been implicated in neurodevelopment and brain ageing, as well as in synapse function and cognitive performance, in both health and disease. ncRNA-mediated processes may be involved in various aspects of the pathogenesis of neurodegenerative disorders. Understanding these events may help to develop novel diagnostic and therapeutic tools. Here, we provide an overview of the complex mechanisms that are affected by the diverse ncRNA classes that have been implicated in neurodegeneration.

中文翻译：

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神经变性中的非编码RNA

转录景观的复杂性给我们对基因组如何调节脑功能和功能障碍的传统观念提出了巨大挑战。非蛋白质编码RNA（ncRNA）在中枢神经系统中赋予各种分子过程高水平的复杂动态调节作用，在健康和心理健康方面，它们都与神经发育和大脑衰老以及突触功能和认知表现有关。疾病。ncRNA介导的过程可能涉及神经退行性疾病的发病机制的各个方面。了解这些事件可能有助于开发新颖的诊断和治疗工具。在这里，我们提供了复杂机制的概述，这些复杂机制受神经退行性疾病影响的各种ncRNA类的影响。