Herein, we report the investigation of sodium deoxycholate (NaDC)/TRIS-based hydrogels as delivery vehicles for a broad range of applications. Three hydrogel formulations were chosen for unique rheological behaviors that suggest a change in internal hydrogel structure with the application of a shear force. In this work, we compare solute release from sheared and non-sheared hydrogels in order to explore the effect of shear force on structure and release kinetics. It was found that the application of a shear force, in addition to changes in temperature, drug solubility, drug concentration, and hydrogel formulation each affected the amount of solute ultimately released from a hydrogel system. Moreover, the use of the inherent chirality of the hydrogel network for enantio-preferential drug release was also explored. We show significant enantio-preference in the release of model drugs tryptophan and ibuprofen from the hydrogel network. Furthermore, hydrophobic domains within the hydrogel network were exploited to enable ibuprofen loading at ten times the maximum water solubility. Retention of enantio-preference was observed at this higher ibuprofen concentration. Cyclodextrin modification to the hydrogel matrix allowed for enantio-preferential inversion which is an unprecedented observation.

在此，我们报告了基于脱氧胆酸钠（NaDC）/ TRIS的水凝胶作为输送载体的研究，其应用范围很广。选择了三种水凝胶制剂用于独特的流变行为，这些行为表明在施加剪切力后内部水凝胶结构发生了变化。在这项工作中，我们比较溶质从剪切和非剪切水凝胶中的释放，以探讨剪切力对结构和释放动力学的影响。已经发现，除了温度，药物溶解度，药物浓度和水凝胶制剂的变化以外，施加剪切力均影响最终从水凝胶系统释放的溶质的量。此外，还探索了水凝胶网络的固有手性用于对映优先药物释放。我们在从水凝胶网络释放模型药物色氨酸和布洛芬中显示出显着的对映体偏好。此外，利用水凝胶网络中的疏水域使布洛芬的负载量达到最大水溶性的十倍。在较高的布洛芬浓度下观察到对映体偏好的保留。对水凝胶基质进行环糊精修饰可实现对映-优先转化，这是前所未有的发现。