Responsive molecular designs to specific biosignals in microenvironments endow site-specific functionalities with associated polymers. Thus, the construction of small interfering RNA (siRNA) carriers with functional polymers enables smart programs that are triggered by sequential biosignals in a pathway to the targeted cytosol for effective gene silencing. In this review, we explain rational strategies for the design of functional polymers with responsiveness to biosignals and describe the examples of smart carriers for siRNA delivery.

中文翻译：

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基于聚合物的功能性siRNA传递载体，可识别位点特异性生物信号

对微环境中特定生物信号的响应分子设计赋予了相关聚合物特定于位点的功能。因此，利用功能性聚合物构建小的干扰RNA（siRNA）载体可实现智能程序，这些程序可通过通往目标细胞质的途径中的顺序生物信号触发，以实现有效的基因沉默。在这篇综述中，我们解释了对生物信号具有响应性的功能性聚合物设计的合理策略，并描述了用于siRNA传递的智能载体的实例。