One-Step Fast Synthesis of Nanoparticles for MRI: Coating Chemistry as the Key Variable Determining Positive or Negative Contrast,Langmuir

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One-Step Fast Synthesis of Nanoparticles for MRI: Coating Chemistry as the Key Variable Determining Positive or Negative Contrast
Langmuir ( IF 3.7 ) Pub Date : 2017-09-18 00:00:00 , DOI: 10.1021/acs.langmuir.7b01759
Juan Pellico ₁ , Jesús Ruiz-Cabello _{1,

2} , Irene Fernández-Barahona ₁ , Lucía Gutiérrez _{3,

4} , Ana V. Lechuga-Vieco ₁ , Jose A. Enríquez ₁ , M. Puerto Morales ₃ , Fernando Herranz ₁

Affiliation

Iron oxide nanomaterial is a typical example of a magnetic resonance imaging probe for negative contrast. It has also been shown how this nanomaterial can be synthesized for positive contrast by modification of the composition and size of the core. However, the role of the organic coating in the relaxometric properties is largely unexplored. Here, maghemite nanoparticles with either excellent positive or very good negative contrast performance are obtained by modifying coating thickness while the core is kept unchanged. Different nanoparticles with tailored features as contrast agent according to the coating layer thickness have been obtained in a single-step microwave-driven synthesis by heating at different temperatures. A comprehensive analysis is conducted of how the composition and structure of the coating affects the final magnetic, relaxometric, and imaging performance. These results show how the organic coating plays a fundamental role in the intrinsic relaxometric parameters of iron oxide-based contrast media.

中文翻译：

一步法快速合成用于MRI的纳米粒子：涂层化学是确定正或负对比度的关键变量

氧化铁纳米材料是磁共振成像探头用于负对比度的典型示例。还已经显示出如何通过改变芯的组成和尺寸来合成该纳米材料以获得正反差。然而，有机涂层在弛豫特性中的作用在很大程度上尚待探索。在此，通过在核心保持不变的情况下改变涂层厚度，可以获得具有优异的正或非常好的负对比性能的磁赤铁矿纳米粒子。通过在不同温度下加热，在一步微波驱动的合成中，已获得了根据涂层厚度不同而具有特定特征的作为对比剂的纳米颗粒。对涂层的成分和结构如何影响最终的磁性进行了全面的分析，弛豫和成像性能。这些结果表明，有机涂层如何在基于氧化铁的造影剂的固有弛豫参数中发挥基本作用。

更新日期：2017-09-19

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