Four new cyclic heptapeptides, mortiamides A–D (1–4), were obtained from a novel Mortierella sp. isolate obtained from marine sediment collected from the intertidal zone of Frobisher Bay, Nunavut, Canada. The structures of the compounds were elucidated by NMR spectroscopy and tandem mass spectrometry. The absolute configurations of the amino acids were determined using Marfey’s method. Localization of l and d amino acids within each compound was ascertained by retention time comparison of the partial hydrosylate products of each compound to synthesized dipeptide standards using LC-HRMS. Compounds 1–4 did not exhibit any significant antimicrobial or cytotoxic activity.

中文翻译：

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Mortiamides A–D，来自新型Mortierella sp。的环状七肽。从弗罗比舍湾获得

四个新的环状七肽，mortiamides A-d（1 - 4）中，从一个新得到的被孢霉属。从加拿大努纳武特Frobisher湾潮间带收集的海洋沉积物中分离得到的分离物。通过NMR光谱和串联质谱法阐明了化合物的结构。氨基酸的绝对构型是使用Marfey方法确定的。通过使用LC-HRMS比较每种化合物的部分氢解产物与合成的二肽标准品的保留时间，可以确定每种化合物中l和d氨基酸的定位。化合物1 - 4 没有表现出任何显着的抗微生物或细胞毒活性。