Isolation, Synthesis, and Biological Activity of Chlorinated Alkylresorcinols from Dictyostelium Cellular Slime Molds,Journal of Natural Products

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Isolation, Synthesis, and Biological Activity of Chlorinated Alkylresorcinols from Dictyostelium Cellular Slime Molds
Journal of Natural Products ( IF 3.3 ) Pub Date : 2017-09-18 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00456
Haruhisa Kikuchi ₁ , Ikuko Ito ₁ , Katsunori Takahashi ₂ , Hirotaka Ishigaki ₂ , Kyoichi Iizumi ₃ , Yuzuru Kubohara ₃ , Yoshiteru Oshima ₁

Affiliation

Eight chlorinated alkylresorcinols, monochasiol A–H (1–8), were isolated from the fruiting bodies of Dictyostelium monochasioides. Compounds 1–8 were synthesized to confirm their structures and to obtain sufficient material for performing biological tests. Monochasiol A (1) selectively inhibited the concanavalin A-induced interleukin-2 production in Jurkat cells, a human T lymphocyte cell line. Monochasiols were biogenetically synthesized by the combination of biosynthetic enzymes relating to the principal polyketides, MPBD and DIF-1, produced by Dictyostelium discoideum.

中文翻译：

Dictyostelium细胞粘液霉菌中的氯化烷基间苯二酚的分离，合成及生物活性

八个氯化烷基间苯二酚，monochasiol A-H（1 - 8），从子实体中分离盘基网柄monochasioides。化合物1 - 8合成，以确认它们的结构，并获得足够的材料用于进行生物测试。Monochasiol A（1）在人T淋巴细胞细胞系Jurkat细胞中选择性抑制伴刀豆球蛋白A诱导的白介素2的产生。单壳酚是通过与Disctyostelium discoideum生产的与主要聚酮化合物MPBD和DIF-1有关的生物合成酶的组合生物合成的。

更新日期：2017-09-18

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