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Dynamic Light Scattering Investigation of the Kinetics and Fidelity of Supramolecular Copolymerizations in Water
Macromolecules ( IF 5.1 ) Pub Date : 2017-09-18 00:00:00 , DOI: 10.1021/acs.macromol.7b01561 Patrick Ahlers 1 , Karl Fischer 1 , Daniel Spitzer 1 , Pol Besenius 1
Macromolecules ( IF 5.1 ) Pub Date : 2017-09-18 00:00:00 , DOI: 10.1021/acs.macromol.7b01561 Patrick Ahlers 1 , Karl Fischer 1 , Daniel Spitzer 1 , Pol Besenius 1
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The self-assembly of supramolecular copolymers facilitates the preparation of multifunctional materials, with tunable mechanical, electronic, or bioactive properties. Compared to covalent copolymerization protocols, controlling the molecular weight, stability, and monomer sequence of a multicomponent supramolecular copolymer remains limited. Here, we report a light scattering investigation of the charge-regulated supramolecular copolymerization in neutral buffer of physiological ionic strength, supported with electron microscopy and circular dichroism spectroscopy experiments. Dendritic anionic and cationic peptide comonomers self-assemble into AB-type heterocopolymers with a nanorod-like morphology, a thickness of 11 nm, and a mean length of up to 70 nm. The fidelity in the copolymerization is remarkably high, and excess of either monomer of up to 50 mol % in the feed ratio does not lead to chain stoppering. The narrow length distribution of the copolymers (Đ < 1.3) and high colloidal stability in physiological buffer support their applications as biomedical carrier materials.
中文翻译：
水中超分子共聚动力学和保真度的动态光散射研究
超分子共聚物的自组装促进了具有可调的机械，电子或生物活性特性的多功能材料的制备。与共价共聚方案相比，控制多组分超分子共聚物的分子量，稳定性和单体序列仍然受到限制。在这里，我们报告了在电离显微镜和圆二色光谱实验的支持下，在生理离子强度的中性缓冲液中电荷调节的超分子共聚的光散射研究。树突状阴离子和阳离子肽共聚单体自组装成具有纳米棒状形态，厚度为11 nm，平均长度不超过70 nm的AB型杂聚物。共聚反应的保真度非常高，进料比中最多50摩尔％的任何一种单体的过量都不会导致链停止。共聚物的窄长度分布（Đ <1.3）和在生理缓冲液中的高胶体稳定性支持了它们作为生物医学载体材料的应用。
更新日期：2017-09-18
中文翻译：
水中超分子共聚动力学和保真度的动态光散射研究
超分子共聚物的自组装促进了具有可调的机械，电子或生物活性特性的多功能材料的制备。与共价共聚方案相比，控制多组分超分子共聚物的分子量，稳定性和单体序列仍然受到限制。在这里，我们报告了在电离显微镜和圆二色光谱实验的支持下，在生理离子强度的中性缓冲液中电荷调节的超分子共聚的光散射研究。树突状阴离子和阳离子肽共聚单体自组装成具有纳米棒状形态，厚度为11 nm，平均长度不超过70 nm的AB型杂聚物。共聚反应的保真度非常高，进料比中最多50摩尔％的任何一种单体的过量都不会导致链停止。共聚物的窄长度分布（Đ <1.3）和在生理缓冲液中的高胶体稳定性支持了它们作为生物医学载体材料的应用。
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