Direct Palladium-Catalyzed Carbonylative Transformation of Allylic Alcohols and Related Derivatives,Organic Letters

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Direct Palladium-Catalyzed Carbonylative Transformation of Allylic Alcohols and Related Derivatives
Organic Letters ( IF 4.9 ) Pub Date : 2017-09-18 00:00:00 , DOI: 10.1021/acs.orglett.7b02801
Fu-Peng Wu ₁ , Jin-Bao Peng ₁ , Lu-Yang Fu ₁ , Xinxin Qi ₁ , Xiao-Feng Wu _{1,

2}

Affiliation

A direct, palladium-catalyzed, carbonylative transformation of allylic alcohols for the synthesis of β,γ-unsaturated carboxylic acids has been developed. With formic acid as the CO source, various allylic alcohols were conveniently transformed into the corresponding β,γ-unsaturated carboxylic acids with excellent linear and (E)-selectivity. The reaction was performed under mild conditions; toxic CO gas manipulation and high-pressure equipment were avoided in this procedure.

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