Described herein is a convenient and highly selective synthesis of alkynylated isoquinolines and biisoquinolines from various aryl ketone O-pivaloyloxime derivatives and 1,3-diynes via rhodium-catalyzed C–H bond activation. In this transformations, alkynylated isoquinolines, 3,4′- and 3,3′-biisoquinolines could be obtained respectively through changing the reaction conditions. Mechanistic investigation revealed that the C–H activation of aryl ketone O-pivaloyloxime was the key step to this reaction.

中文翻译：

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Rh ^III催化的C–H活化/ 1,3-二炔策略选择性合成炔基化异喹啉和双异喹啉

本文描述的是通过铑催化的C–H键活化，由各种芳基酮O-新戊酰肟衍生物和1,3-二炔方便而高度选择性地合成炔基化异喹啉和双异喹啉。在该转化中，通过改变反应条件，可以分别获得炔基化的异喹啉，3,4'-和3,3'-二异喹啉。机理研究表明，芳基酮O-新戊酰肟的C–H活化是该反应的关键步骤。