Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell-based Compound Discovery and Target Prediction,Angewandte Chemie International Edition

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Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell-based Compound Discovery and Target Prediction
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2017-09-18 11:39:21 , DOI: 10.1002/anie.201707394
Lea Kremer _{1,

2} , Carsten Schultz-Fademrecht ₃ , Matthias Baumann ₃ , Peter Habenberger ₃ , Axel Choidas ₃ , Bert Klebl ₃ , Susanne Kordes _{3,

4} , Hans R. Schöler ₄ , Jared Sterneckert _{4,

5} , Slava Ziegler ₁ , Gisbert Schneider ₆ , Herbert Waldmann _{1,

2}

Affiliation

Better together: Joint application of chemical biology and computational target prediction enabled the identification of the pyrazolo-imidazole derivative smoothib as a novel inhibitor of hedgehog signaling and the membrane protein smoothened as its target.

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