Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-Targeted Bioactive Ligands,Angewandte Chemie International Edition

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Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-Targeted Bioactive Ligands
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2017-09-18 11:37:58 , DOI: 10.1002/anie.201707641
Brittany S. Morgan ₁ , Jordan E. Forte ₁ , Rebecca N. Culver ₁ , Yuqi Zhang ₂ , Amanda E. Hargrove ₁

Affiliation

A space for RNA: The curation and analysis of the RNA-targeted BIoactive ligaNd Database (R-BIND) uncovered distinguishing 2D and 3D molecular properties that support the existence of an RNA-privileged chemical space. These guiding principles can facilitate the future design of selective ligands targeted toward therapeutically relevant RNAs.

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