Brain-derived neurotrophic factor (BDNF), the TrkB ligand, is associated with aggressive malignant behavior, including migration and invasion, in tumor cells and a poor prognosis in patients with various types of cancer. Delphinidin is a diphenylpropane-based polyphenolic ring structure-harboring compound, which exhibits a wide range of pharmacological activities, anti-tumor, anti-oxidant, anti-inflammatory, anti-angiogenic and anti-mutagenic activity. However, the possible role of delphinidin in the cancer migration and invasion is unclear. We investigated the suppressive effect of delphinidin on the cancer migration and invasion. Thus, we found that BDNF enhanced cancer migration and invasion in SKOV3 ovarian cancer cell. To exam the inhibitory role of delphinidin in SKOV3 ovarian cancer migration and invasion, we investigated the use of delphinidin as inhibitors of BDNF-induced motility and invasiveness in SKOV3 ovarian cancer cells in vitro. Here, we found that delphinidin prominently inhibited the BDNF-induced increase in cell migration and invasion of SKOV3 ovarian cancer cells. Furthermore, delphinidin remarkably inhibited BDNF-stimulated expression of MMP-2 and MMP-9. Also, delphinidin antagonized the phosphorylation of Akt and nuclear translocation of NF-κB permitted by the BDNF in SKOV3 ovarian cancer cells. Taken together, our findings provide new evidence that delphinidin suppressed the BDNF-induced ovarian cancer migration and invasion through decreasing of Akt activation.

TrkB配体是脑源性神经营养因子（BDNF），与肿瘤细胞中的侵袭性恶性行为（包括迁移和侵袭）相关，并且各种癌症患者的预后不良。Delphinidin是具有二苯丙烷基的多酚环结构的化合物，具有广泛的药理活性，抗肿瘤，抗氧化剂，抗炎，抗血管生成和抗诱变活性。但是，德尔菲尼丁在癌症迁移和侵袭中的可能作用尚不清楚。我们调查了飞燕草素对癌症迁移和侵袭的抑制作用。因此，我们发现BDNF增强了SKOV3卵巢癌细胞中的癌症迁移和侵袭。为了检查飞燕草素在SKOV3卵巢癌迁移和侵袭中的抑制作用，体外。在这里，我们发现飞燕草素显着抑制了BDNF诱导的SKOV3卵巢癌细胞迁移和侵袭的增加。此外，飞燕草素显着抑制了BDNF刺激的MMP-2和MMP-9的表达。此外，飞燕草素拮抗SKOV3卵巢癌细胞中Akt的磷酸化和BDNF所允许的NF-κB的核易位。综上所述，我们的发现提供了新的证据，表明delphinidin通过降低Akt激活抑制了BDNF诱导的卵巢癌迁移和侵袭。