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A rapid and highly efficient Michael addition of methoxybenzenes and indoles to α,β-unsaturated ketones using BF3·OEt2 as a catalyst
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2017-09-18 , DOI: 10.1016/j.tetlet.2017.09.016
A. Swetha , M. Raghavender Reddy , B. Madhu Babu , H.M. Meshram

An efficient and general protocol is described for the Michael addition of α,β-unsaturated ketones with electron-rich arenes/indoles to give alkylated arenes/indoles under mild reaction condition at room temperature. Shorter reaction time, convenient and good isolated yields are the significant features of this protocol. Moreover, the procedure is environmentally benign in nature and applicable to variety of arenes/indoles as well as α,β-unsaturated ketones.



中文翻译:

使用BF 3 ·OEt 2作为催化剂,快速高效地将甲氧基苯和吲哚迈克尔加成到α,β-不饱和酮上

描述了一种有效且通用的方案,用于在室温下在温和的反应条件下,将α,β-不饱和酮与富电子的芳烃/吲哚进行迈克尔加成反应,以生成烷基化的芳烃/吲哚。较短的反应时间,方便的分​​离产率和良好的收率是该方案的重要特征。而且,该方法本质上是环境友好的,并且适用于多种芳烃/吲哚以及α,β-不饱和酮。

更新日期:2017-09-18
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