Tetrahedron Letters ( IF 1.5 ) Pub Date : 2017-09-17 , DOI: 10.1016/j.tetlet.2017.09.027 Richard S Belisle 1 , Christopher W Via 1 , Tracey B Schock 2 , Tracy A Villareal 3 , Paul V Zimba 4 , Kevin R Beauchesne 5 , Peter D R Moeller 5 , Matthew J Bertin 1
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Mass spectrometry-guided isolation of the lipophilic extract of Trichodesmium bloom material led to the isolation and structure characterization of a new thiazole-containing di-chlorinated polyketide (1). The structure of 1 was deduced using 1D and 2D NMR analysis, high-resolution mass spectrometry analysis and complementary spectroscopic procedures. Trichothiazole A possesses interesting structural features, such as a terminal alkyne, two vinyl chlorides and a 2,4-disubstituted thiazole. Trichothiazole A showed moderate cytotoxicity to Neuro-2 A cells (EC50: 13.3 ± 1.1 μM).
中文翻译：
Trichothiazool A，一种二氯化聚酮化合物，含有从 Trichodesmium 水华中分离出的嵌入噻唑
通过质谱引导分离木藻水华材料的亲脂性提取物，从而分离出一种新的含噻唑二氯化聚酮化合物并进行结构表征 ( 1 )。 1的结构是利用一维和二维核磁共振分析、高分辨率质谱分析和补充光谱程序推导出来的。 Trichothiazool A 具有有趣的结构特征，例如末端炔烃、两个氯乙烯和 2,4-二取代噻唑。 Trichothiazool A 对 Neuro-2 A 细胞显示出中等的细胞毒性 (EC 50 : 13.3 ± 1.1 μM)。
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