If SPRINT (Systolic Blood Pressure Intervention Trial) eligibility criteria were applied to the 1999 to 2006 NHANES (National Health and Nutrition Examination Survey), Bress and colleagues¹ calculate that lowering systolic blood pressure (BP) to an intensive goal of <120 mm Hg (versus the standard goal of <140 mm Hg) could prevent ≈107 500 deaths per year, despite a higher incidence of treatment-related serious adverse events.

A sensitivity analysis has tried to take into account the different methods of BP measurements in NHANES and SPRINT, finding reduced but still significant outcomes.

The SPRINT methodology is not usually used in clinical practice. BP was measured at an office visit, in participants sitting quietly …

如果将SPRINT（收缩压干预试验）资格标准应用于1999年至2006年的NHANES（国家健康与营养检查调查），则Bress及其同事¹计算出将收缩压（BP）降低至<120 mm Hg的强化目标（相对于<140 mm Hg的标准目标），尽管与治疗相关的严重不良事件发生率更高，但每年仍可预防约107500例死亡。

敏感性分析已尝试考虑NHANES和SPRINT中BP测量的不同方法，发现结果减少但仍然很显着。

SPRINT方法学通常不在临床实践中使用。BP是在一次办公室拜访中测量的，参与者安静地坐着……