Late-stage chemoselective functional-group manipulation of bioactive natural products with super-electrophilic silylium ions

Nature Chemistry, Published online: 18 September 2017; doi:10.1038/nchem.2863

Determining the structure­–activity relationships for complex structures can be quite challenging, but it is often the method in which many natural products can be used as drugs. Now, the combination of a fluoroaryl borane catalyst, a phosphine additive and a silane reducing agent enables the late-stage selective modification of complex bioactive natural products.

中文翻译：

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具有超亲电子性硅离子的生物活性天然产物的后期化学选择性官能团操作

具有超亲电子性硅离子的生物活性天然产物的后期化学选择性官能团操作

《自然化学》，在线发布：2017年9月18日; doi：10.1038 / nchem.2863

确定复杂结构的结构-活性关系可能非常具有挑战性，但通常这是将许多天然产物用作药物的方法。现在，氟芳基硼烷催化剂，膦添加剂和硅烷还原剂的组合可以对复杂的生物活性天然产物进行后期选择性修饰。